CeliacAdvanced

| CeliacAdvanced |

Nathaniel Ethan

This page is intended for other grown-ups like my Mommy who want to understand in depth what's going on with their kids.

Interpreting Bloodwork

Anti-Gliadin Antibodies........(AGA).......IgA

A result of less than 20 is considered a negative result for the antibody. A result of 20-30 is considered to be a "weak positive". A result of more than 30 is considered to be a moderate or strong positive.

Virtually 100% of those with POSITIVE IgA anti-gliadin antibodies have celiac.

Anti-Gliadin Antibodies........(AGA).......IgG

Over 90% of those with POSITIVE IgG anti-gliadin antibodies have celiac. (Note: Up to 10% of those with positive IgG anti-gliadin antibodies do NOT have celiac.)

Anti-Endomysium Antibodies........(EMA).......IgA

Virtually 100% of those with Celiac are POSITIVE for IgA antiendomysium antibodies after eating gluten.

100% of those with Celiac on carefully restricted diets are NEGATIVE for IgA antiendomysium antibodies.

An absence of these antibodies in a person who eats gluten is considered definitive that they are NOT Celiac.

Anti-Reticulin Antibodies........( ).....IgA

There are five types of antireticulin antibodies. Only one of these is associated with celiac disease, though it is very specific for celiac disease. Virtually 100% of those POSITIVE for this antibody after eating gluten have Celiac.

Combined Results

Rare Celiac patients who are also IgA deficient will make IgG antibodies. In this case, only the AGA can be used to correctly diagnose Celiac.

The presence of two of these three antibodies- Circulating IgA-gliadin, antireticulin, and antiendomysial- raises the probablity of definitive diagnosis even more.

http://www.fbr.org/publications/resguide99/rg-tl04.html

http://www.aetna.com/cpb/data/CPBA0561.html

http://www.fbr.org/publications/resguide99/

The Development & Diagnosis of Celiac

Celiac is an autoimmune disease which may occur as the result of a viral infection in people who are already genetically predisposed to Celiac.

If you want to avoid diagnostic surgery like my Mommy did for me, try these blood tests for diagnostic confirmation instead:
.....IgG antigliadin antibodies
.....IgA antigliadin antibodies
.....antireticulin antibodies
.....antiendomysial antibodies
.....antitissue transglutaminase antibodies.

http://www.enabling.org/ia/celiac/predic.html

The Oats Controversy

Within the confines of a discussion of Celiac, the term gluten is used to refer to "peptides derived from prolamins (proteins) that include the harmful amino acid sequences found in wheat."

Wheat, rye, and barley have prolamins that contain the toxic sequences.

Adults with NON-severe Celiac seem to be able to tolerate oats IF the oats have not been cross-contaminated.

The amount of oats tolerated, the long-term effect of oats, and the importance of contamination still needs to be more thoroughly investigated.

The Journal of Pediatric Gastroenterology and Nutrition states strongly that oats are NOT safe for children with celiac. They do not comment on adults.

Contamination of commercial oats is common, as oats and wheat are often processed at the same plants, and transported in the same vehicles. Oats and wheat are also close to the same size, therefore it is very difficult to remove one from the other in an attempt at decontamination.

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